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Brown Macular Lesions. Ephilides Neurofibromatosis Albright's disease Peutz Jeghers syndrome Xeroderm pigmentosum Xeroderma pigmentosum (XP) is characterized by sun sensitivity, ocular involvement, and greater than 1000-fold increased risk of cutaneous and ocular neoplasms. Approximately 50% of affected individuals demonstrate acute sun sensitivity from early infancy, acquiring severe sunburn with blistering or persistent erythema on minimal sun exposure; marked freckling of sun-exposed areas in a child under age two years is typical of XP and rarely seen in normal children. Acropigmentation Central lentigines Seborrheic keratosis Neurocutaneous melanosis Nieman-Pick disease Niemann-Pick disease (NPD) comprises an autosomal recessively inherited group of congenital lipidoses in which sphingolipids accumulate in cells, especially reticuloendothelial cells, throughout the body. Melasma (Chloasma Kwashiokor Photochemical reactions Berlock dermatitis Ultraviolet light (sun tan) Thermal radiation Becker's nevus Hemochromotosis Hereditary hemochromatosis (HH) is the most prevalent mono-allelic genetic disorder in whites. It should be considered in persons with hepatomegaly, abnormal liver tests, increased skin pigmentation, diabetes, heart disease (arrhythmias e.g. atrial fibrillation, PVC's), arthritis, and hypogonadism. Testing can be done by a combination of the following tests: serum ferritin, serum iron and TIBC, genetic testing, and liver biopsy. Post-inflammatory hyperpigmentation Malignant melanoma Lentigo melanoma Mastocytosis (urticaria pigmentosa) Cronkhite - Canada syndrome Tatoo Reticular acropigmentation of Kitamura Dermatopathia pigmentosa reticularis Riehl's melanosis Franceschetti - Jadassohn syndrome Gaucher's disease Dyskeratosis congenita Addison's disease Date: 2015-01-11; view: 1008
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