Theme: Mesenchymal degenerations

Validation of the subject: studying the subject is necessary for understanding of the other subjects of general pathology. It is also a guide to study pathomorphlogy of diseases (infectious, allergic, rheumatic as well as hypertension, atherosclerosis, kidney diseases, endocrinopathy). The knowledge of the cause and pathogenesis of mesenchymal degeneration is very important for understanding of clinical disciplines when studying them and also for medical practice.

Objective of the lesson:to study the aetiology, pathogenesis, classification of morphological changes in the connective tissues; possible outcomes and significance of mesenchymal degeneration in organ dysfunction.

Visual aids

Annotated tables:connective tissue structure; morphogenesis of mesenchymal degeneration;morphogenesis of amyloidosis;classification of amyloidosis

Coloured tables:hyalinosis;amyloidosis;fat metabolism dysfunction;specific microscopic staining for amyloid detection.

Slides:"sago spleen";hyalinosis of the spleen artery;arterilosclerotic nephrosclerosis;obesity of the heart (fatty heart).

Gross specimen:"sago spleen";sebaceous (waxy) spleen;kidney amyloidosis;glased spleen (sugar-icing spleen);hyalinosis of scars;general obesity - adipose tissue;fat capsule of the kidney; obesity of the heart (fatty heart).

Microscopic specimen:mucoid swelling of the aorta wall in atherosclerosis;hyalinosis of the spleen arteriole;amyloidosis of the spleen (sago spleen);amyloidosis of the liver;obesity of the heart.

Questions to control basic knowledge:

1)Is amyloidosis a type of carbohydrate degeneration?

2)Name the types of mesenchymal protein degeneration: a)mucoid swelling b)turbid swelling c)hyalinosis d)amyloidosis e)hyaline-drop degeneration f)fibrinoid swelling.

3)What structures are changed in mucoid swelling: a) collagenous fibres b)hepatocytes c)main substance of connective tissue d)epithelium of convoluted tubules

4) Classify for 1 - protein; 2 - fatty; 3 - carbohydrate mesenchymal degeneration: a)fibrinoid swelling b) general obesity c) amyloidosis d) mucoid swelling e) hyalinosis f) mucus degeneration

Answers: 1) no; 2) a, c, d, f; 3) a, c; 4) 1 - a, c, d, e; 2 - b; 3 - f.

Stages of individual work in class

Study and describe gross specimen:

Hyalinosis of the spleen capsule (glazed spleen, sugar-icing spleen). Describe spleen capsule, colour, texture, outlook. Characterize the nature of capsule changing. Give the definition of the process, indicate previous condition. Characterize the level of reversibility.

Amyloidosis of the spleen (sago spleen). Describe the dimensions of the organ, its texture, colour, appearance on the section. Indicate the nature of process, localization of amyloid. Define the process, indicate the steps of morphogenesis. Name specific microscopic staining for amyloid

Amyloidosis of the spleen (sebaceous or waxy spleen). Describe the dimensions of the organ, its texture, colour, appearance on the section. Indicate localization of amyloid. Determine the difference between «sebaceous» and «sago» spleen.

Amyloidosis of the kidney.Describe the dimensions of the organ, its texture, the width of cortical layer, the appearance of the surface on the section. Name the diseases which can result in amyloidosis of kidney. What its prognosis?

Obesity of the heart (fatty heart).Determine the dimensions of the organ. Pay attention to the quality of fat under the epicardium. Pay attention to the growth of fatty tissue in the heart wall on the section, more developed in the right portions. Characterize the type of impaired fat metabolism. Name the aetiology and mechanisms of general obesity development, its significance, outcome.

Atherosclerosis of the aorta. Characterize the appearance, colour of the aortic intima. Define the nature of the changes, explain the mechanism of their development, significance for the organism.

Date: 2016-03-03; view: 1270