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A genetic disorder is an illness caused by one or more abnormalities in the genome.

 

Just as money makes money, so knowledge already acquired facilitates the acquisition of more knowledge. It is equally evident in the case of the method, which will now engage our attention. The progress of science, and of knowledge generally, is frequently facilitated by supplementing the simpler inductive methods by deductive reasoning from knowledge already acquired. Such a combination of deduction with induction, J. S. Mill called the "Deductive Method," by which he really meant the "Deduc­tive Method of Induction." To avoid the confusion of the "De­ductive Method" with mere deduction, which is only one part of the whole method, it is better to describe it as the "Deductive-Inductive Method" or the "Inductive-Deductive Method." Mill distinguished two principal forms of this method as applied to the study of natural phenomena, -namely, (1) that form of it in which deduction precedes induction, and (2) that in which induc­tion precedes deduction. The first of these (1) he called the "Physical Method"; the second (2) he called the "Historical Method."

These names are rather misleading, inasmuch as both forms of the method are frequently employed in physics, where some­times, say in the study of light, mathematical (i.e., deductive) calculations precede and suggest physical experiments (i.e., induc­tion), and sometimes the inductive results of observation or ex­periment provide the occasion or stimulus for mathematical de­ductions. In any case, the differences in order of sequence are of no great importance, and hardly deserve separate names. What is of importance is to note the principal kinds of occasion, which call for the use of this combined method. They are mainly three in number: (1) When an hypothesis cannot be verified (i.e., tested) directly, but only indirectly; (2) when it is possible to systematise a number of already established inductions, or laws, under more comprehensive laws or theories; (3) when, owing to the difficulties of certain problems, or on account of the lack of sufficient and suitable instances of the phenomena under in­vestigation, it is considered desirable either to confirm an induc­tive result by independent deductive reasoning from the nature of the case in the light of previous knowledge, or to confirm a deductive conclusion by independent inductive investigation.

An example of each of these types may help to make them clear. (1) When Galileo was investigating the law of the velocity of falling bodies he eventually formed the hypothesis that a body starting from rest falls with a uniform acceleration, and that its velocity varies with the time of its fall. But he could not devise any method for the direct verification of this hypothesis. By mathematical deduction, however, he arrived at the conclusion that a body falling according to his hypothetical law would fall through a distance proportionate to the time of its fall. This consequence could be tested by comparing the distances and the time of falling bodies, which thus served as an indirect verifica­tion of his hypothesis. (2) By inductions from numerous astro­nomical observations made by Tycho Brahe and himself, Kepler discovered the three familiar laws called by his name, namely, (a) that the planets move in elliptic orbits which have the sun for one of their foci; (6) that the velocity of a planet is such that the radius vector (i.e., an imaginary line joining the moving planet to the sun) sweeps out equal areas in equal periods of time; and (c) that the squares of the periodic times of any two planets (that is, the times which they take to complete their revolutions round the sun) are proportional to the cubes of their mean distances from the sun. These three laws appeared to be quite independent of each other. But Newton systematised them all in the more comprehensive induction, or theory, of celestial gravitation. He showed that they could all be deduced from the one law that the planets tend to move towards each other with a force varying directly with the product of their masses, and inversely with the square of the distances between them. (3) H. Spencer, by comparing a number of predominantly industrial States and also, of predominantly military States, ancient and modern, inferred inductively that the former type of State is democratic and gives rise to free institutions, whereas the latter type is undemocratic and tends to oppression. As the sparse evidence hardly permitted of a rigorous application of any of .the inductive methods, Spencer tried to confirm his conclusion by deductive reasoning from the nature of the case in the light of what is known about the human mind. He pointed out that in a type of society, which is predominantly industrial, the trading relations between individuals are the predominant relations, and these train them to humour and consider others. The result is a democratic attitude in all. In a State, which is predominantly military, the relations which are most common among its members are those of authority, on the one part, and of subordination on the other. The result is the reverse of a democratic atmosphere.



 

RELATION OF EPISTEMOLOGY TO OTHER BRANCHES OF PHILOSOPHY

 

In conclusion, I would like to discuss the relation of epistemology to other branches of philosophy. Philosophy viewed in the broadest possible terms divides into many branches: metaphysics, ethics, aesthetics, logic, philosophy of language, philosophy of mind, philosophy of science, and a gamut of others. Each of these disciplines has its special subject matter: for metaphysics it is the ultimate nature of the world; for ethics, the nature of the good life and how people ideally ought to comport themselves in their relations with others; and for philosophy of science, the methodology and results of scientific activity. Each of these disciplines attempts to arrive at a systematic understanding of the issues that arise in its particular domain. The word systematic is important in this connection, referring, as explained earlier, to the construction of sets of principles or theories that are broad-ranging, consistent, and rationally defensible. In effect, such theories can be regarded as sets of complex claims about the various matters that are under consideration.

Epistemology stands in a close and special relationship to each of these disciplines. Though the various divisions of philosophy differ in their subject matter and often in the approaches taken by philosophers to their characteristic questions, they have one feature in common: the desire to arrive at the truth about that with which they are concerned--say, about the fundamental ingredients of the world or about the nature of the good life for man. If no such claims were asserted, there would be no need for epistemology. But, once theses have been advanced, positions staked out, and theories proposed, the characteristic questions of epistemology inexorably follow. How can one know that any such claim is true? What is the evidence in favour of (or against) it? Can the claim be proven? Virtually all of the branches of philosophy thus give rise to epistemological ponderings.

These ponderings may be described as first-order queries. They in turn inevitably generate others that are, as it were, second-order queries, and which are equally or more troubling. What is it to know something? What counts as evidence for or against a particular theory? What is meant by a proof? Or even, as the Greek Sceptics asked, is human knowledge possible at all, or is human access to the world such that no knowledge and no certitude about it is possible? The answers to these second-order questions also require the construction of theories, and in this respect epistemology is no different from the other branches of philosophy. One can thus define or characterise epistemology as that branch of philosophy, which is dedicated to the resolution of such first- and second-order queries.

 

 

BIBLIOGRAPHY:

 

1.A preface to the logic of science, by Peter Alexander, Sheed and Ward, London and New York, 1963.

 

2.Popper selections, edited by Dawid Miller, Princeton University press, 1985.

 

3.The critical approach to science and philosophy, edited by Mario Bunge, The free press of Glencoe Collier- Magmillan limited, London, 1964.

 

4.Britannica encyclopaedia, 1948.

 

5.Logic without metaphysics, by Ernest Nagel, Glencoe, Ill..: Free Press, 1957.

 

6."Epistemology, History of,", by D.W. Hamlyn. The Encyclopaedia of Philosophy.

7. Introduction to Objectivist Epistemology, expanded 2nd ed., by Ayn Rand, New York: Penguin Group, 1990.

 

A genetic disorder is an illness caused by one or more abnormalities in the genome.

Autosomal dominant:

Only one mutated copy of the gene will be necessary for a person to be affected by an autosomal dominant disorder. Each affected person usually has one affected parent. The chance a child will inherit the mutated gene is 50%.

Following examples are for autosomal dominant:

Huntington's disease

(HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It typically becomes noticeable in mid-adult life. HD is the most common genetic cause of abnormal involuntary writhing movements called chorea, which is why the disease used to be called Huntington's chorea. A child of an affected person typically has a 50% chance of inheriting the disease. Physical symptoms of Huntington's disease can begin at any age from infancy to old age, but usually begin between 35 and 44 years of age. The Huntingtin gene provides the genetic information for a protein that is also called "huntingtin". Expansion of a CAG (cytosine-adenine-guanine) triplet repeat stretch within the Huntingtin gene results in a different (mutant) form of the protein, which gradually damages cells in the brain, through mechanisms that are not fully understood. Huntington's disease is one of the "poly-glutamine" diseases, which means that in the gene for the huntingtin protein (Htt), there is a run of several repeats of the codon CAG - which codes for glutamine (normally less than 36 repeats).

If you have more than 36 CAG repeats, it is more and more likely that your DNA polymerase will "slip" when copying this region, and will accidentally insert extra CAGs (as it cannot tell *which* CAG it has slipped onto). This leads to more and more CAGs, which accelerate the slippage. It also leads to more and more glutamines being included in the Htt protein.

Marfan syndrome

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Polycystic kidney disease

It is a cystic genetic disorder of the kidneys. PKD is characterized by the presence of multiple cysts. The disease can also damage the liver, pancreas and, in some rare cases, the heart and brain. 85% of mutations in ADPKD occur in chromosome 16 (PKD1 gene). This gene pair makes a protein called polycystin-1 (PC-1).


Date: 2014-12-21; view: 1091


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