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INTERACCCION ETANOL - MEDICAMENTO Y POSIBLES EFECTOS

ETANOL-MEDICAMENTO EFECTOS
Etanol-Acido acetil salicílico (Needham et al, 1971) Riesgo de gastrolesividad
Etanol-Acido Valpróico (Anon, 1978). Potencialización de efectos sedantes
Etanol-Acetaminofén (Sato et al, 1981) Riesgo de hepatotoxicidad
Etanol-Analgésicos Opiodes (Bellville et al, 1971) Riesgo de depresión respiratoria
Etanol-Anticonceptivos (Jones & Jones, 1984) Potencialización de efectos sedantes
Etanol-Antidepresivos Tricíclicos( Seppala et al, 1975) Potencialización de efectos sedantes
Etanol-Antihistamínicos (Burns & Moskowitz, 1980) Potencialización de efectos sedantes
Etanol-Antipsicóticos(Freed, 1981, Gebhart, 1969) Aumento de sedación y extrapiramidalismos
Etanol-Barbitúricos (Khanna et al, 1988) Mayor riesgo de sedación y dep. respiratoria
Etanol-Benzodiacepinas (Welling, 1984; Laisi, 1979) Mayor riesgo de sedación y dep. respiratoria
Etanol-Metformin (Prod Info Glucophage(R), 1999) Posible riesgo de acidosis láctica
Etanol-Bromocriptina (Prod Info Parlodel®, 1997) Intolerancia al medicamento
Etanol-Bupropión (Prod Info Wellbutrin®, 1999) Riesgo aumentado de convulsiones
Etanol-Cefalosporinas (Childs & Kosola, 1982) Posible efecto antabuse
Etanol-Doxiciclina (Hansten, 1979) Disminuye de los efectos del antibiótico
Etanol-Fenitoína (Schmidt, 1975;Finer, 1971) Disminuye los niveles séricos de fenitoína
Etanol-Fenobarbital (Misra et al, 1971; Khanna et al,1988) Agudo: Aumentan niveles séricos de fenob. Crónico: Disminuyen niveles séricos de fenob.
Etanol-Furazolidona (AMA, 1986) Efecto antabuse en 5 a 20% de ptes durante 4.d.
Etanol-Furazolidona (AMA, 1986) Efecto antabuse en 5 a 20% de ptes durante 4 d.
Etanol-Insulina (Arky et al, 1968) Riesgo de hipoglucemia
Etanol-Isoniazida (Prod Info INH®, 1993) Efecto antabuse, hepatotoxicidad.
Etanol-Ketoconazol (Magnasco & Magnasco, 1986) Efecto antabuse por 48 horas, hepatotoxicidad
Etanol-Metotrexate (Almeyda et al, 1971) Aumento de la hepatotoxicidad
Etanol-Metoclopramida (Prod Info Reglan®, 1996) Potencialización de efectos sedantes
Etanol-Metronidazol (Penick et al, 1969) Posible efecto antabuse durante 3 días
Etanol-Nitritos (Allison et al, 1971). Hipotensión por vasodilatación
Etanol-Propranolol (Grabowski et al, 1980) Disminuye la absorción y elimina propranolol.
Etanol-Ranitidina (Arora et al, 2000) Aumento en la concentración del etanol.
Etanol-Sulfonilúreas (Stockley, 1983; Leslie & Pyke, 1978) Posible efecto antabuse e hipoglicemia
Etanol-Trimetropim Sulfa (Heelon & White, 1998) Posible efecto antabuse
Etanol-Verapamilo (Bauer et al, 1992) Aumento de la alcoholemia y riesgo de sedación
Etanol-Warfarina (Cropp & Bussey, 1997) Aumento del efecto anticoagulante

 



CONCLUSIÓN

Es necesario el conocimiento de las interacciones medicamentos-alimentos para garantizar un adecuado efecto terapéutico, minimizar la posibilidad de interacciones y efectos adversos. Para ello el equipo muiltidisciplinario constituido por la nutricionista, enfermera, farmacéutico y médico deben trabajar en estrecha relación.

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