Belarus’ National Academy of Sciences presents top ten scientific results of 2015.
A study which resulted in chemical combinations being discovered achieved the top of the scientific table: these are to be used for developing a drug against the 20th century plague: AIDS. In modern science, significant discoveries are often made on the edge of disciplines, as seen by this recent work by the Bioorganic Chemistry Institute and the United Institute of Informatics Problems, where methods of molecular modelling have been used by chemists.
The project leader and chief scientific officer at the United Institute of Informatics Problems, Doctor of Chemical Sciences Alexander Andrianov, has been investigating computer modelling methods for potential drugs against AIDS for about a decade. This enormous task is assisted by the Institute’s Supercomputer Centre. HIV has been thoroughly studied and it wasn’t too long ago that antibodies were detected to fight against it. Those whose immune systems create these antibodies will not suffer from AIDS. Our scientists have set a goal to find chemical combinations which would have interacted with HIV, involving coated proteins similar to these antibodies.
“Our major goal in this project was the computer screening of extensive databases of chemical combinations. There are millions of them; it’s impossible to do without large capacity computers. Initially, we select the combinations which potentially have the required features. Later, these are used to choose the molecules that will specifically and efficiently interact with functionally important parts of the virus. This has involved many calculating experiments,” commented Professor Alexander Tuzikov, the Director of the United Institute of Informatics Problems and a corresponding member of Belarus’ National Academy of Sciences. He adds that it took many months for a team of researchers to solve the problem, using supercomputer resources. As a result, several dozen combinations have been identified; at least in computer experiments, they are able, in theory, to neutralise the AIDS virus. Around ten years ago, a search such as this was manual, involving much finance, time and effort. After the advent of modern virtual testing, much hope is pinned on real experiments as they are necessary to objectively assess whether a combination is efficient or not in fighting the virus.
By Alexander Bogomazov
Äàòà ïóáëèêàöèè: 12:53:30 03.02.2016
Gene at the end of the tunnel
Leukaemia is found each year in 60-80 young people and nearly 240 adults in our country. The efficiency in curing it in many respects depends on how quickly and precisely diagnosis is carried out. Experts are constantly striving to try to improve their methods. One new example of this is the Laboratory of Genetic Biotechnology at the Republican Scientific and Practical Centre for Paediatric Oncology, Haematology and Immunology, where a test-system for the diagnosis of genetic abnormalities among children with acute leukaemia has been developed. Within a very short period of time it will allow us to not only understand what kind of blood cancer a patient is suffering from, but also to define the best approach for treatment. The work has been recognised as the best in its category at the Republican contest of innovative projects.
Genetic changes in cells lead to leukaemia. If these can be identified at an early stage, we can gain valuable information from them, for example, as to what medication the illness is most susceptible. The disease which once was called ‘blood cancer’ is now subdivided into approximately 70 categories, of these, approximately eighteen subgroups are acute leukaemias. The test-system allows doctors to study up to 20 genes, important for diagnosing and understanding the disease.
“First, it helps to make diagnosis precise and to choose the optimum therapy depending on the type of acute leukaemia. Secondly, there is a possibility of using targeted medications based on the genetic changes revealed by the tests. Thirdly, such diagnostics are important for assessing the efficiency of treatment and tracking the remaining cancerous cells. As we know, genetic change is the characteristic of these cells, for us it is a disease marker. If during subsequent analyses there are no changed cells, it means in all probability the patient is in remission and additionally, their presence will help to define and prevent the return of the disease,” Anatoly Kustanovich, Head of the Laboratory of Genetic Biotechnology discusses the possibilities of the method.
Initially, the Republican Scientific and Practical Centre was developing its own test-system to make diagnosis more effective, to find a convenient method which would be used by a small team of analysts and would allow doctors to receive the information quickly. As a result, now it takes just a day: if the cell material of patients with leukaemia arrives at the laboratory in the morning, then the result could be ready by the evening. Anatoly Kustanovich confirms it is only a part of the diagnostic process and the choice of therapy is not based only on this test; a range of other measures are also carried out. In addition, the test-system is flexible and can be adapted to solve different problems, for example, by increasing the number of defined genes.
Thanks to this latest development, a further advantage is that it will allow import substitution, a constant goal of the government. The Republican Republican Scientific and Practical Centre has recently considered using the Danish company HemaVision for the study of acute leukaemia; however, it was necessary to refuse the contract because of difficulties with the purchases and the high cost of analysis, at 100 Euros per person. The cost price of similar research using our own test-system is 10 times less. The new method is now at the patenting stage. The benefits from it will not only be economic, but also social: one more ally in the struggle against this devastating illness is welcomed.