Kg of Acetylsalicylic acid

Purifying the aspirin to pure acetylsalicylic acid. All the guides I reviewed, around 8, had flawed or even dysfunctional methods. I had to locate an entirely different method from YouTube which proved to work excellently.

Estimated time required: 4 days to purchase the product in a secure manner (assuming each apothecary has a 2 box cap). You would need to set up an "apothecary route" visiting 20-30 apothecaries in one day, then wait 1-2 weeks for safety and repeat 3 more times the next 4-8 weeks. As soon as you have all the aspirin it will require 10 minutes to pulverize it with a regular stationary or handheld blender and approximately 2 days to synthesize.

Other reagents needed: distilled water, mineral and distilled ice cubes: around 40-50 liters

You will need purified aspirin equivalent to 2,5kg of aspirin tabs/270 boxes of 20 tabs (mostly containing 440mg (producer: Nycomed, brand name: Globoid) but about 1/6th was a different brand containing 500mg tabs (producer: Bayer, brand name: Aspirin). You will be synthesizing 1,6 kg or more of pure acetylsalicylic acid from 2,5 kg of impure aspirin tablets. The reason you need to purify the aspirin is to remove the 17% of so called "fillers", stark etc. The maximum yield of pure acetylsalicylic acid you can extract from aspirin is 83%, if I remember correctly. I managed to extract aprox 67% (1,68kg out of 2,5kg) which is a good yield. It's worth noting that all the guides I could locate online were either incorrect or significantly flawed. All the guides I read failed to inform me that if you heat the aspirin to more than 70C it will destroy the acetyl and convert it to salicylic acid which is worthless for our purpose.

Of course, I had to learn it the hard way and managed to create a lot of worthless goo... Fortunately, I eventually managed to locate a method that worked optimally and I only ruined the first batch.

a. Grinding the aspirin; some retarded guides suggested I use a mortar and pestle... Needless to say, after a few hours, my wrists hurt like hell, and I realized this was an extremely poor method for the quantities I was working with. There must be a better way? I ended up experimenting and I found a very nice method. I put out a large plastic sheet on the floor and poured aprox 1000 tabs on it, spreading it evenly. I then used a 20kg dumbbell (single hand weight used for weight training) and crushed the tabs with even strokes by using gravity. It took me less than 4 hours to crush all the tabs. In retrospect I realize that using a blender would be even better. Providing you use a blender (I prefer stationary, but I guess handheld works as well) which assures a good and even spread/circulation as you grind them (same principle as when grinding AN prills) it should only take you 10 minutes to grind up 2,5kg of aspirin tabs. It's worth buying several brands of blenders to find out which offers the best circulation. Basically; only 1 out of 5 blenders offers appropriate circulation. Handheld blenders are probably the exception here since your motion determine the circulation, providing you grind it in an appropriately shaped container. With circulation I mean that as the lower part of the tabs gets grinded to fine dust, the heavy pieces of the tabs rise to the top until they are "sucked" down the "downward whirling current" - providing optimal grinding. I bought a total of 8 different blenders and only 2 of them worked efficiently for this purpose (at least for AN prill grinding). When completed; you now have 2,5kg of fine aspirin powder.

Date: 2015-12-17; view: 579