INFLUENCE OF USE OF ANSP DURING ABDOMINAL OPERATIONS ON THE FUNCTIONAL STATE OF ENERGETIC HOMEOSTASIS

H.F.HUSEYNOV, F.E.ABBASOV, N.C.BAYRAMOV, L.V.KOSTRU

Scientific Center of Surgery named after acad. M.A. Topchubashov, Central Hospital of SCC, Baku, AZERBAIJAN

Introduction. Coordinated study of changes in the exchange of energy resources of carbohydrate and lipid origin under the influence of surgical aggression, has not still found its rational solution despite its great scientific and practical importance from the point of view of determining of their pathogenesis and regulation principles. Especially, during abdominal operation and early post-operative period, there is a great need in more detailed staties aimed at the study of the influence of the use of anti-inflammatory nonsteroid preparations (ANSP) on the main indicators of energetic homeostatis.

Materials and methods. 18 patients that underwent abdominal open and laparoscopic surgery were before the intervention intravenously injected 100 mg of Ketonal solution, and on the 1^st and 2^nd post-surgical days, rectal suppositories(Voltaren 50 mg) were used each 8 hours (main group). The nature and intensity of changes in the energetic homeostasis system were assessed based on the changes in the level of energy resources of carbohydrate (glucose and lactate) and lipid (SYT and TQ) origin. Results of the examinations were compared with the control group (22 patients).

Results. Examinations carried out immediately after surgical intervention and in the 1-2^nd and post-surgical days showed that the content of glucose in the blood of patients in which ANSP were used, was respectively 11,2% and 12,3% (P<0,05), and the content of lactate 45,0% and 25,4% (P<0,01) less than in the control group. At the same time, there was significant difference between compared groups according to the level of energy resources of lipid origin – at the end of surgical intervention and on the 1-2^nd and 3-5^th post-surgical days there was observed that in the blood of the main group the content of SYT was respectively 72,5%, 36,9% and 63,5% (P<0,01), and the content of TQ - respectively 45,6%, 37,5% and 25,2% less (P<0,05) than in the control group.

Conclusion. Due to powerful antistressor influence of the use of ANSP in the process of the surgical treatment prevents unnecessary mobilization (lipolysis) of SYT from the adipose tissue by significant weakening of the intensity of hyperglycemic response of organism to surgical aggression.

Date: 2014-12-28; view: 921