CORRELATIONS BETWEEN AGGREGATION ACTIVITY OF BLOOD CELLS AND PARAMETERS OF MICROCIRCULATION IN PATIENTS WITH CHRONIC PANCREATITIS

N.M. BURDULI, S.K. GUTNOVA

SEIof HPE North-Ossetian State Medical Academy, Vladikavkaz, RUSSIA

Introduction. Chronic pancreatitis (CP) is a particularly spread disease in recent years, and constituted 9% in the total morbidity of digestive organs. The disease main affects people of working age, and the average age of diagnosis has reduced to 39 years.

The aim of our study was to identify the relationship between the aggregation ability of blood cells and microcirculation in patients with CP in the exacerbation phase.

Materials and methods. A total of 67 people were analyzed (55 women and 12 men). The main group included 47 patients with CP in the exacerbation phase, the average age of patients was 56,5 ± 4,3 years, mean duration of anamnesis 8,03 ± 2,3 years. The control group consisted of 20 healthy persons. Aggregation properties of platelets and erythrocytes were studied byBorn’sturbodimetricmethod byusing aggregation analyzer of the AR 2110hemoagregometer, of the SOLAR company (Belarus). Microcirculation investigation was conducted by the method of laser Doppler flowmetry (LDF) on the LAKK-02 device (production of the NPO “Lazma”, Russia). The obtained data was processed by the method of variational statistics. For pair interactions of signs there was used correlation analysis with calculation of Pearson coefficient (r).

Results.One of the main factors that is able to disturb the normal character of the microcirculatory blood flow, is the aggregation of shaped blood elements, as demonstrated by the correlation analysis between the parameters of microcirculation and aggregation of platelets and erythrocytes, which revealed moderate negative relationship between the degree of aggregation of platelets and the efficiency index of microcirculation (r = -0.51), the rate of erythrocyte aggregation and indicator of efficiency of the microcirculation (r =- 0,52), rate of erythrocyte aggregation and an indicator of respiratory samples (r = +0,54).

Conclusion. Thus, the conducted correlation analysis shows the relationship between the aggregation function of platelets, erythrocytes and the state of microcirculation in patients with chronic pancreatitis in the exacerbation phase.

Date: 2014-12-28; view: 846